LCZ696 ENTRESTO TM

Name	Sacubitril\|Valsartan
Synonyms	LCZ696 LZC696 Entresto LCZ696 Entresto LCZ696 ENTRESTO TM Sacubitril mixture with Valsartan Cocrystal of Sacubitril and Valsartan [(C24H29N5O3).(C24H29NO5).2.5(H2O).3Na] 4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate
CAS	936623-90-4
EINECS	000-000-0

Molecular Formula	C48H58N6O8
Molar Mass	847.03
Solubility	10 mM in DMSO
Storage Condition	-20℃
In vivo study	In double transgenic rats overexpressing human renin and angiotensinogen and Plasma atrial natriuretic peptide immunoreactivity, LCZ696 (60 mg/kg p.o.) causes a dose-dependent and persistent decrease in mean arterial pressure (MAP) and stimulates a rapid dose-dependent increase in plasma ANP immunoreactivity. LCZ696 (68 mg/kg p.o.) attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing myocardial fibrosis and hypertrophy in a rat myocardial infarction (MI) model. In double transgenic rats overexpressing human renin and angiotensinogen and Plasma atrial natriuretic peptide immunoreactivity, LCZ696 (60 mg/kg p.o.) causes a dose-dependent and persistent decrease in mean arterial pressure (MAP) and stimulates a rapid dose-dependent increase in plasma ANP immunoreactivity. LCZ696 (68 mg/kg p.o.) attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing myocardial fibrosis and hypertrophy in a rat myocardial infarction (MI) model.

Last Update：2024-01-02 23:10:35

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CAS: 936623-90-4
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CAS: 936623-90-4
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Spot supply

Product Name: Entresto (LCZ696) Visit Supplier Webpage Request for quotation
CAS: 936623-90-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Spot supply

Product Name: LCZ696 Visit Supplier Webpage Request for quotation
CAS: 936623-90-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: Sacubitril/Valsartan Request for quotation
CAS: 936623-90-4
Tel: 0531-88990216
Email: fairouz@sdsihuanpharm.com
Mobile: 13335127975
QQ: 824027327

Send QQ message

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LCZ696 ENTRESTO TM

LCZ696 ENTRESTO TM Request for Quotation